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JUNFANG WU

 

 

 

Ph.D. (Neuropharmacology) 1995, Nanjing University, China
Phone: 202.687.0226
Fax: 202.687.0617
E-mail: jw365@georgetown.edu

 

 

Dr. Wu’s research has focused on the cellular interaction and signal transduction mechanism of spinal cord injury. In particular, she was the first to discover that spinal cord injury lead to up-regulation of CHL1 expression in activated astrocytes. This novel observation along with mechanism study in vivo and in vitro illustrates a dual functions of CHL1 depending on its spatial and temporal expression: conductive and inhibitory. We will determine the cell types that express this inhibitory molecule after spinal cord injury, their fate, and how its expression is altered by chemicals/drugs. The long term significance of her work is to understand the cellular and molecular mechanism of functional recovery after spinal cord injury and also to develop potentially therapeutic strategies. In addition, she has extensive research interesting and experience on the neuroprotection study on stroke and also on signal transduction mechanisms in various animal models with cognitive deficits.

PUBLICATIONS

  1. Jakovcevski I, Wu J, Karl N, Leshchyns'ka I, Sytnyk V, Chen J, Irintchev A, and Schachner M. Glial Scar Expression of CHL1, the Close Homolog of the Adhesion Molecule L1, Limits Recovery after Spinal Cord Injury. J. Neurosci., 2007, 27: 7222 - 7233.
  2. Chen J, Wu J, Apostolova I, Skup M, Irintchev A, Kügler S, and Schachner M. Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury. Brain, 2007, 130: 954-969.
  3. Huang FL, Huang KP, Wu J, and Boucheron C. Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice. J. Neurosci., 2006, 26(23):6230-7.
  4. Wu J, Huang KP and Huang FL. Participation of NMDA-mediated phosphorylation and oxidation of neurogranin in the regulation of Ca2+- and Ca2+/calmodulin-dependent neuronal signaling in the hippocampus.J. Neurochem., 2003, 86(6):1524-33.
  5. Wu J, Li J, Huang KP, and Huang FL. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse. J. Biol. Chem., 2002, 277(22):19498-505.
  6. Zhu CJ, Wu JF, Qu ZW, Chen LM, and Zhang JT. Bioequivalence evaluation of two sertraline tablet formulations in healthy male volunteers after a single dose administration. Int. J. Clin. Pharmacol. Ther., 1999, 37(3):120-4.
  7. Wu JF and Zhang JT. Antagonistic effect of nerve growth factor on neuronal injury induced by hypoxia in cultured cerebral cortical neurons of rats. Zhongguo Yao Li Xue Bao, 1999, 20(1):47-51.
  8. Zhang JT, Duan WZ and Wu JF. Gene regulation of apoptosis and study of anti-neuronal apoptotic agents [article in Chinese]. Yao Xue Xue Bao, 1998, 33(1):75-9.
  9. Wu JF, Liu TP, Wang JX, and Yang SJ. Effect of berberine on intracellular free CA2+ concentration in cultured brain cells [article in Chinese]. Yao Xue Xue Bao, 1997,32(1):15-8.
  10. Wu JF and Liu TP. Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion [article in Chinese]. Yao Xue Xue Bao, 1995, 30(2):98-102.