Ph.D., 1991, Harvard University (Toxicology)
Phone: 202.687.1534
Fax: 202.687.0617
E-mail: gwr2@georgetown.edu

We study the molecular mechanisms of Alzheimer's disease using a variety of approaches, including genetics, immunohistochemistry and cell biology. Only one common genetic risk factor for Alzheimer's disease has been identified so far: APOE. This gene encodes a protein involved in cholesterol transport and cellular repair in the periphery We are exploring these processes in the central nervous system in order to understand how apoE (and lipid metabolism) alters one's risk of Alzheimer's disease. Our current research focuses on the role of cholesterol in the metabolism of the Ab peptide and on the signaling functions of apoE receptors.

In addition, we are interested in a related dementing illness, amyloid angiopathy. In this condition, the Ab peptide deposits in blood vessels of the brain, leading to gradual dementia or sudden hemorrhagic stroke. We recently identified a mutation in the Ab precursor protein that causes a familial form of amyloid angiopathy. Present studies also include quantitative immunohistological analyses and animal models.

Medline Publications