Ph.D. 2002, Genetic Engineering, Sungkyunkwan University, Korea
Phone: 202.687.1620
Fax: 202.687.0617
E-mail: hh69@georgetown.edu
Dr. Hoe's research focuses on ApoE (known to be a high risk factor for Alzheimer's disease), APP and ApoEr2 signaling pathways and the mechanism by which the ApoE4 allele affects AD disease. Building on previous research findings that several adaptor proteins affect APP processing and Abeta production, Dr. Hoe is investigating the role of ligands and their functional effects, including neurite outgrowth, synapse formation, and spine formation, on neuronal migration. Evidnece indicates that ligands play a key role in AD pathology and suggest a molecular basis for the reveral of memory loss which could lead to new therapeutic approaches to treat the disease.
Medline Publications
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