Ph.D. 2002, Genetic Engineering, Sungkyunkwan University, Korea
Phone: 202.687.1620
Fax: 202.687.0617
E-mail: hh69@georgetown.edu

Dr. Hoe's main interests include ApoE, APP and ApoEr2 signaling pathways. ApoE is a high risk factor for Alzheimer's disease; however, the mechanism by which the ApoE4 allele affects Alzheimer's disease has not been well studied. One factor that may affect the processing of ApoEr2 is ligand-binding. We have found a new ligand for ApoEr2, F-spondin. F-spondin is also a ligand for APP, and acts as a link between APP and ApoEr2 via their extracellular domains, forming a complex, finally decreasing A#61538. Recent research is focusing on finding other new ligands for APP and ApoEr2, and especially further analyzing the functional effects of these complexes, including neurite outgrowth, synapse formation, and spine formation. Previously, we have found that several adaptor proteins such as Fe65 and Dab1 also affect APP processing and Abeta production. Interestingly, recent papers have shown that APP, Fe65, Dab1, and ApoEr2 are all involved in neuronal migration. Mice with defects in these molecules exhibit neuronal deficits. Therefore, we are also conducting functional analyses of these complexes of molecules to investigate their effects on neuronal migration.

Medline Publications