M.D., 1971,
University of Chicago
Phone: 202.687.0492
Fax: 202.687.4143
E-mail: fadena@georgetown.edu
Dr.
Faden's research addresses pathobiological mechanisms of neuronal
cell death at the molecular and cellular levels, and the development
of novel neuroprotective treatment strategies. The program is highly
interdisciplinary, utilizing molecular and cellular biology, biochemistry,
electrophysiology, pharmacology, behavior, magnetic resonance imaging
and spectroscopy, and quantitative histological analysis. There
are 4 major lines of investigation.
- Examining
mechanisms of cell death in development and CNS injury, using
a variety of in vivo models (rat/mouse head injury, rat/mouse
spinal cord injury) and in vitro models (trauma/stretch injury,
chemical ischemia) with particular emphasis on the apoptotic-necrotic
continuum.
- Elucidating
the role of metabotropic glutamate receptors (mGluR) in posttraumatic
cell death, and delineating the signal transduction pathways
involved and the role of neuronal-glial interaction.
- Using temporal
gene profiling to evaluate signal transduction pathways and gene-gene
interactions in traumatic brain and spinal cord injury.
- Developing
novel neuroprotective agents in collaboration with several drug
discovery groups.
Laboratory
for the Study of Central Nervous System Injury
Medline
Publications
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